Real Madrid boss Jose Mourinho rested key players at the weekend including the likes of Xabi Alonso, Angel Di Maria and Mesut Ozil - all are set to return.
Teenage sensation Raphael Varane and full-back Fabio Coentrao also missed the game against Real Zaragoza with slight injuries, and are expected to return to the line-up.
However, Madrid legend Iker Casillas will be sitting on the bench after not fully recovering from a hand injury, which means Diego Lopez will start in goal.
Former Bolton striker Johan Elmander is in the Galatasaray squad as he recovers from a foot injury which has seen the Sweden international out for two months.
Didier Drogba will spearhead the Turkish side's attack and Mourinho will know all about him after their time at Chelsea, but the Portuguese should be wary of Burak Yilmaz who is the joint top scorer in the competition.